Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein
US11400162B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Sep 4, 2018 |
| Grant date | Aug 2, 2022 |
| Priority date | — |
| Expiry date | Sep 4, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/6037
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides from Streptococcus pneumoniae to a carrier protein. These process are serotype specific and include acid hydrolysis, addition of sodium chloride to the reductive amination reaction, and addition of sucrose to dissolve polysaccharides. Polysaccharide-protein conjugates prepared using the processes of the invention can be included in multivalent pneumococcal conjugate vaccines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.