Treatment for Wolfram syndrome and other endoplasmic reticulum stress disorders

US11426415B2 · kind B2 · utility

Assignees

• Washington University · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Fumihiko Urano · Chesterfield, US
• Jana Mahadevan · Temecula, US
• Amy Clark · Gainesville, US
• Ajit Jadhav · Chantilly, US
• David J. Maloney · Point of Rocks, US
• Brandon Harvey · Parkville, US
• Shyh-Ming Yang · Doylestown, US
• Mark J. Henderson · Damascus, US

Key dates

• Filing date: Mar 6, 2018
• Grant date: Aug 30, 2022
• Expiry date: Jun 9, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/605
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention generally relates to compositions and methods for treating or preventing an endoplasmic reticulum stress disorder in subjects, including compositions and methods for treating or preventing Wolfram syndrome. The present invention also relates to methods for treating symptoms of neurodegenerative diseases.