T cell balance gene expression, compositions of matters and methods of use thereof

US11427869B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• Massachusetts Institute of Technology · US
• President and Fellows of Harvard College · US
• The Brigham and Women's Hospital, Inc. · US
• The Regents of the University of California · US

Inventors

• Aviv Regev · Cambridge, US
• Vijay K. Kuchroo · Newton, US
• Jellert Gaublomme · Cambridge, US
• Youjin Lee · Suwon-si, KR
• Chao Wang · State College, US
• Nir Yosef · Richmond, US
• Hongkun Park · Lexington, US
• James J. Kaminski · Lawrence, US

Key dates

• Filing date: Aug 25, 2017
• Grant date: Aug 30, 2022
• Expiry date: Mar 14, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.