Processes for preparing pyrrolidine compounds

US11434201B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Paul Angell · Carlsbad, US
• Robert Michael Hughes · San Diego, US
• Berenice Lewandowski · Braintree, US
• Benjamin Littler · Carlsbad, US
• William A. Nugent · Wilmington, US
• David Smith · Newton, US
• John Studley · Abingdon, GB

Key dates

• Filing date: Aug 2, 2018
• Grant date: Sep 6, 2022
• Expiry date: May 21, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/263
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Processes for preparing 5,5-dimethyl-3-methylenepyrrolidin-2-one, (S)-3,5,5-trimethylpyrrolidine-2-one, (R)-3,5,5-trimethylpyrrolidine-2-one, (S)-2,4,4-trimethylpyrrolidine, and (R)-2,4,4-trimethylpyrrolidine, and their salt forms are disclosed.