Use of physiological cooling active ingredients, and compositions comprising such active ingredients

US11434220B2 · kind B2 · utility

Assignees

• BASF SE
• SYMRISE AG · DE

Inventors

• Benoit Join · Holzminden, DE
• Jekaterina ONGOUTA · Stadtoldendorf, DE
• Michael Backes · Los Angeles, US
• Rahim Brodhage · Rinteln, DE
• Arnold Machinek · Holzminden, DE
• Hubert Loges · Ankum, DE
• Susanne Mundt · Holzminden, DE
• Tom SOMERS · Holzminden, DE
• Thomas Subkowski · Schriesheim, DE
• Jens Wittenberg · Schifferstadt, DE
• Martin WEISEL · Mannheim, DE
• Wolfgang Siegel · Schifferstadt, DE
• Claus Bollschweiler · Heidelberg, DE
• Ralf Pelzer · Rastenberg, DE

Key dates

• Filing date: Aug 31, 2018
• Grant date: Sep 6, 2022
• Expiry date: Aug 31, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A23V2002/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.