Patent · US Active

Method for generating retinal pigment epithelium (RPE) cells from induced pluripotent stem cells (IPSCs)

US11441184B2 · kind B2 · utility

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26Claims

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Assignee

The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

Kapil Bharti · Potomac, US
Janine Davis · Baltimore, US
Arvydas Maminishkis · Washington, US
Sheldon S. Miller · Berkeley, US

Key dates

Filing date	Sep 27, 2019
Grant date	Sep 13, 2022
Priority date	—
Expiry date	May 8, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/178
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

High efficiency methods for producing retinal pigment epithelial cells from induced pluripotent stem cells (iPSCs) are disclosed herein. The iPSCs are produced from somatic cells, including retinal pigment epithelial (RPE) cells, such as fetal RPE stem cells. In some embodiments, the iPSC include a tyrosinase promoter operably linked to a marker. Methods are disclosed for using the RPE cells, such as for treatment. Methods for screening for agents that affect RPE differentiation are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.