Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
US11464774B2 · kind B2 · utility
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104References
14Claims
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Key dates
| Filing date | Sep 30, 2016 |
| Grant date | Oct 11, 2022 |
| Priority date | — |
| Expiry date | Sep 30, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a DNA damaging agent and between about 12 and about 48 hours later administering to the subject a compound that inhibits ATR protein kinase. Methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a compound that inhibits ATR protein kinase are also described. Exemplary ATR inhibitors are represented by Formulae A-I and A-II or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.