Synthesis of disorazoles and analogs thereof as potent anticancer agents
US11465997B2 · kind B2 · utility
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19Claims
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Assignee
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Key dates
| Filing date | Jun 21, 2018 |
| Grant date | Oct 11, 2022 |
| Priority date | — |
| Expiry date | Jun 21, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D515/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In one aspect, the present disclosure provides disorazole analogs of the formula: Formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.