Cyclic dinucleotides as sting agonists

US11472830B2 · kind B2 · utility

Assignee

• JANSSEN BIOTECH, INC. · US

Inventors

• Gilles Bignan · Bound Brook, US
• Peter J. Connolly · New Providence, US
• James P. Edwards · San Diego, US
• Stuart Emanuel · Doylestown, US
• Sylvie Laquerre · King of Prussia, US
• Tianbao Lu · Collegeville, US
• Mark Richter · Wayne, US
• Leonid Beigelman · San Mateo, US
• Santhosh Kumar Thatikonda · Woburn, US
• Guangyi Wang · Carlsbad, US
• Minghong Zhong · Lo Wu, CN

Key dates

• Filing date: Nov 22, 2017
• Grant date: Oct 18, 2022
• Expiry date: Feb 22, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating viral infections, diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R1A, R1B, R1c, B1, R2A, and R2B are defined herein.