Inventor · San Mateo, CA, US

Leonid Beigelman

225Patents
38h-index
141Co-inventors
93Inventor score

Filing activity: Mar 29, 1994 → May 23, 2024

Most-cited inventions

PatentTitleAreaCited byStatus
US5627053A 2'deoxy-2'-alkylnucleotide containing nucleic acid Chemistry; Metallurgy 481 Expired
US5998203A Enzymatic nucleic acids containing 5'-and/or 3'-cap structures Chemistry; Metallurgy 308 Expired
US6159951A 2'-O-amino-containing nucleoside analogs and polynucleotides Chemistry; Metallurgy 128 Expired
US5716824A 2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes) Chemistry; Metallurgy 118 Expired
US7176304B2 RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) Chemistry; Metallurgy 108 Expired
US8871737B2 Substituted nucleotide analogs Emerging Cross-Sectional Technologies 107 Active
US6673611B2 Nucleic acid molecules with novel chemical compositions capable of modulating gene expression Chemistry; Metallurgy 103 Expired
US8202979B2 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid Emerging Cross-Sectional Technologies 93 Expired
US6248878A Nucleoside analogs Chemistry; Metallurgy 92 Expired
US6117657A Non-nucleotide containing enzymatic nucleic acid Chemistry; Metallurgy 83 Expired
US8273866B2 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA) Chemistry; Metallurgy 81 Active
US8648185B2 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) Emerging Cross-Sectional Technologies 80 Active
US8618277B2 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) Chemistry; Metallurgy 79 Active
US6849726B2 Non-nucleotide containing RNA Chemistry; Metallurgy 77 Expired
US8980865B2 Substituted nucleotide analogs Chemistry; Metallurgy 76 Active
US6395713B1 Compositions for the delivery of negatively charged molecules Chemistry; Metallurgy 74 Expired
US7923547B2 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) Chemistry; Metallurgy 70 Active
US7109165B2 Conjugates and compositions for cellular delivery Human Necessities 66 Expired
US9249174B2 Substituted nucleosides, nucleotides and analogs thereof Chemistry; Metallurgy 64 Active
US9181551B2 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) Chemistry; Metallurgy 63 Active
US6617438B1 Oligoribonucleotides with enzymatic activity Chemistry; Metallurgy 63 Expired
US8772474B2 Cyclic nucleotide analogs Emerging Cross-Sectional Technologies 55 Active
US9243022B2 Substituted nucleosides, nucleotides and analogs thereof Chemistry; Metallurgy 55 Active
US8877731B2 Azido nucleosides and nucleotide analogs Chemistry; Metallurgy 54 Active
US6469158B1 Synthesis, deprotection, analysis and purification of RNA and ribozymes Emerging Cross-Sectional Technologies 53 Expired

Source: USPTO / EPO open patent data. Inventor disambiguation is heuristic; counts are objective bibliographic measures.