Modified clostridial neurotoxins as vaccines and conjugate vaccine platforms
US11491239B2 · kind B2 · utility
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Key dates
| Filing date | Dec 17, 2018 |
| Grant date | Nov 8, 2022 |
| Priority date | — |
| Expiry date | Dec 17, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are engineered non-catalytic, non-toxic tetanus toxin variants and methods of using such engineered tetanus toxin variants as low dose, protective vaccines that are non-toxic and more potent than their respective chemically inactivated toxoids. In addition, provided herein are conjugate vaccine carriers comprising engineered tetanus toxin variants and methods of using such conjugate vaccines to elicit T-cell dependent immune memory responses which can target a broad spectrum of microbial pathogens as a single vaccine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.