Macrocyclic indole derivatives

US11492358B1 · kind B1 · utility

Assignees

• The Broad Institute, Inc. · US
• BAYER HEALTHCARE LLC · DE
• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Sarah Anna Liesa Johannes · Düsseldorf, DE
• Philipp Buchgraber · Leverkusen, DE
• Ulrich Klar · Berlin, DE
• Clara Christ · Leverkusen, DE
• Kai Thede · Leverkusen, DE
• Joachim Kuhnke · Leverkusen, DE
• Manfred Moewes · Leverkusen, DE
• Knut Eis · Berlin, DE
• Amaury Ernesto Fernandez-Montalvan · Leverkusen, DE
• Nicolas Werbeck · Berlin, DE
• Ursula Mönning · Mölln, DE
• Philip Lienau · Berlin, DE
• Ulrike Sack · Berlin, DE
• Arne Scholz · Berlin, DE
• Michael H. Serrano-Wu · Cambridge, US
• Christopher Lemke · Laval, CA
• David McKinney · Cambridge, US
• Mark Fitzgerald · Cambridge, US
• Christopher G. Nasveschuk · Stoneham, US
• Kiel Lazarski · Cambridge, US
• Steven James Ferrara · Cambridge, US
• Laura Furst · Cambridge, US
• Guo Ping Wei · Richmond, US
• Patrick R. McCarren · Cambridge, US

Key dates

• Filing date: Feb 26, 2021
• Grant date: Nov 8, 2022
• Expiry date: Mar 15, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to macrocyclic indole derivatives of general formula (I) in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.