Cyclic dinucleotides as sting agonists

US11492367B2 · kind B2 · utility

Assignee

• JANSSEN BIOTECH, INC. · US

Inventors

• Stuart Emanuel · Doylestown, US
• Mark Richter · Wayne, US
• Peter J. Connolly · New Providence, US
• James P. Edwards · San Diego, US
• Guangyi Wang · Carlsbad, US
• Santhosh Kumar Thatikonda · Woburn, US
• Leonid Beigelman · San Mateo, US
• Minghong Zhong · Lo Wu, CN
• Gilles Bignan · Bound Brook, US
• Wim Bert Griet Schepens · Sint-Katelijne-Waver, BE
• Marcel Viellevoye · Breda, NL
• Johannes Wilhelmus John F. Thuring · Ekeren, BE

Key dates

• Filing date: Jan 26, 2018
• Grant date: Nov 8, 2022
• Expiry date: Mar 9, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R1B, R1C, R2B, R2C, B1, W, X, Y, Z are defined herein.