Compositions and methods for targeting cancer-specific sequence variations

US11492670B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• DANA-FARBER CANCER INSTITUTE, INC. · US
• INSTITUTO CARLOS SLIM DE LA SALUD, A.C. · MX

Inventors

• William C. Hahn · Boston, US
• Andrew J. Aguirre · Boston, US
• April Cook · Boston, US
• Glenn Cowley · Cambridge, US
• Robin Meyers · Cambridge, US
• David E. Root · Santa Rosa, US
• Aviad Tsherniak · Cambridge, US
• Barbara Weir · Brookline, US
• Francisca Vazquez · Cambridge, US

Key dates

• Filing date: Oct 20, 2016
• Grant date: Nov 8, 2022
• Expiry date: Jan 15, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compositions and methods for targeting cancer-specific DNA sequences, such as copy number amplifications and other types of cancer-specific sequence variations, such as cancer-specific polymorphisms, insertions, or deletions. The present invention provides hereto sequence-specific DNA targeting agents targeting a sequence within the amplified DNA region or a sequence otherwise specific for a cancer cell compared to a non-cancer cell. The invention further relates to methods for treating cancer, comprising administering such sequence-specific DNA targeting agents. The invention further relates to methods for preparing sequence-specific DNA targeting agent, as well as screening methods using the DNA targeting agents.