Compositions and methods for reprogramming somatic cells into induced vasculogenic cells

US11518790B2 · kind B2 · utility

Assignee

• Ohio State Innovation Foundation · US

Inventors

• Daniel Gallego-Perez · Columbus, US
• Ly James Lee · Columbus, US
• Durba Pal · Sherghati, IN
• Subhadip GHATAK · Columbus, US
• Chandan K. Sen · Columbus, US

Key dates

• Filing date: Dec 20, 2017
• Grant date: Dec 6, 2022
• Expiry date: Nov 25, 2038

Classification

• Technology area (CPC —): General

Abstract

Disclosed herein are compositions and methods that involve using compositions containing one or more of ETV2, FOXC2, FLI1 and a miR-200b inhibitor for directly reprogramming somatic cells into induced vasculogenic cells both in vitro and in vivo. These compositions and methods are useful for a variety of purposes, including the development of pro-angiogenic therapies.