Compounds and methods for regulating insulin secretion

US11555031B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• The General Hospital Corporation · US
• INSTITUTO CARLOS SLIM DE LA SALUD, A.C. · MX

Inventors

• Sean Burns · Hingham, US
• Bridget Wagner · Medford, US
• Amedeo Vetere · Cambridge, US

Key dates

• Filing date: Mar 19, 2018
• Grant date: Jan 17, 2023
• Expiry date: Mar 19, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are methods for inducing insulin secretion in a glucose-dependent manner and compounds for use in these methods. The compounds may have the structure of formula I(a): wherein the substituents are as described in the description; or a pharmaceutically acceptable form thereof.