Ultrasmall nanoparticles labeled with Zirconium-89 and methods thereof

US11559591B2 · kind B2 · utility

Assignees

• Memorial Sloan Kettering Cancer Center · US
• Cornell University · IT

Inventors

• Michelle S. Bradbury · Andover, US
• Feng-Jing Chen · New York, US
• Ulrich Wiesner · Ithaca, US
• Kai Ma · Ithaca, US

Key dates

• Filing date: May 17, 2018
• Grant date: Jan 24, 2023
• Expiry date: May 22, 2038

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y15/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are nanoprobes comprising ultrasmall aminated and cRGDY-conjugated nanoparticles labeled with Zirconium-89 (89Zr) and methods of their use. The provided compositions are renally clearable and possess suitable blood circulation half-time, high tumor active targeting capability, dominant renal clearance, low liver accumulation, and a high tumor-to-background ratio. The described nanoprobes exhibit great potential as “target-or-clear” tracers to human subjects for systemic targeted imaging (or treatment) of cancer.