Method for subtyping lymphoma types by means of expression profiling

US11574704B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• British Columbia Cancer Agency Branch · CA
• Arizona Board of Regents on Behalf of the University of Arizona · US
• UNIVERSITAT DE BARCELONA · ES
• HOSPITAL CLÍNIC DE BARCELONA · ES

Inventors

• Louis M. Staudt · Silver Spring, US
• George W. Wright · Rockville, US
• David William Scott · Vancouver, CA
• Joseph M. Connors · Vancouver, CA
• Randy D. Gascoyne · North Vancouver, CA
• Lisa M. Rimsza · Tucson, US
• Elias Campo Guerri · Barcelona, ES
• Raymond Tubbs · Cleveland, US
• Timothy C. Greiner · Gilliatt, US
• James Robert Cook · Shaker Heights, US
• Kai Fu · Omaha, US
• Paul Michael Williams · Great Falls, US
• Chih-Jian Lih · Gaithersburg, US
• Elaine S. Jaffe · Great Falls, US
• Rita M. Braziel · West Linn, US
• Andreas Rosenwald · Würzburg, DE
• Erlend B. Smeland · Oslo, NO
• Wing C. Chan · Pasadena, US
• German Ott · Bietigheim-Bissingen, DE
• Jan Delabie · Toronto, CA
• Dennis Weisenburger · Glendora, US

Key dates

• Filing date: Jan 17, 2020
• Grant date: Feb 7, 2023
• Expiry date: May 1, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/166
• WIPO field: Computer technology
• WIPO sector: Electrical engineering

Abstract

The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.