Differential refractometer for gradient chromatography
US11579079B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jul 22, 2021 |
| Grant date | Feb 14, 2023 |
| Priority date | — |
| Expiry date | Aug 11, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2021/4146
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure describes a differential refractometer for gradient chromatography. In an exemplary embodiment, the differential refractometer includes a solvent delay volume, an eluent flow meter coupled to an eluent inlet of a sample cell, a solvent flow regulator coupled to an outlet of the solvent delay volume and coupled to a solvent inlet of a reference cell, an instrument controller configured to receive the eluent flow rate from the eluent flow meter, configured to receive the solvent flow rate from the solvent flow regulator, configured to receive a flow rate ratio from a flow rate ratio data source, wherein the flow rate ratio indicates a ratio of the eluent flow rate to the solvent flow rate, and an optical bench configured to measure a difference between a refractive index of the eluent present in the sample cell and a refractive index of the solvent present in the reference cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.