Process for synthesis of a phenoxy diaminopyrimidine compound
US11584724B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Apr 18, 2019 |
| Grant date | Feb 21, 2023 |
| Priority date | — |
| Expiry date | Apr 28, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/13
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed herein is a novel process for preparing Compound A free base, 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-iso-propyl-2-methoxybenzenesulfonamide, and a citrate salt of Compound A with simplified chemistry and a high overall yield: Compound A. In one embodiment, the overall yield from the starting material 2-isopropylphenol to Compound A citrate salt is greater than 50%. In another embodiment, the overall yield is greater than 60%. Also disclosed herein are novel salts and solvates of Compound A.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.