Polymorphs and solid forms of (s)-2-((2-((s)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide, and methods of production

US11591345B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Paroma Chakravarty · San Francisco, US
• Chong Han · Foster City, US
• Sean M. Kelly · Williamsville, US
• Karthik Nagapudi · South San Francisco, US
• Scott Savage · Redwood City, US

Key dates

• Filing date: May 15, 2020
• Grant date: Feb 28, 2023
• Expiry date: May 15, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to crystalline polymorph forms of (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide (GDC-0077), having the structure, Formula I:or stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, and processes of preparing the polymorph forms.