Cyclic dinucleotides as sting agonists

US11597746B2 · kind B2 · utility

Assignee

• JANSSEN BIOTECH, INC. · US

Inventors

• Stuart Emanuel · Doylestown, US
• Mark Richter · Wayne, US
• Peter J. Connolly · New Providence, US
• James P. Edwards · San Diego, US
• Guangyi Wang · Carlsbad, US
• Santhosh Kumar Thatikonda · Woburn, US
• Leonid Beigelman · San Mateo, US
• Gilles Bignan · Bound Brook, US
• Wim Bert Griet Schepens · Sint-Katelijne-Waver, BE
• Marcel Viellevoye · Breda, NL
• Johannes Wilhelmus John F. Thuring · Ekeren, BE

Key dates

• Filing date: Jul 16, 2019
• Grant date: Mar 7, 2023
• Expiry date: Aug 14, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H21/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I), wherein R1, R1′, X1, B1, R2, R2′, B2, X2, R3, Z-M-Y, and Y1-M1-Z1 are as defined herein.