Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors

US11608343B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Birgit WILDING · Wien, AT
• Dietrich BOESE · Erzhausen, DE
• Harald Engelhardt · Ebreichsdorf, AT
• Julian FUCHS · Wien, AT
• Ralph NEUMUELLER · Miedling, AT
• Mark PETRONCZKI · Wien, AT
• Dirk Scharn · Wien, AT
• Matthias Treu · Wien, AT

Key dates

• Filing date: Apr 6, 2021
• Grant date: Mar 21, 2023
• Expiry date: Jul 21, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to new [1,3]diazino[5,4-d]pyrimidines and derivatives of Formula (I) wherein the groups R1, R2, R3 and R4 have the meanings given in the claims and specification, their use as inhibitors of HER2 and its mutants, pharmaceutical compositions which contain such compounds and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.