Octahydropyrido[1,2-alpha]pyrazines as MAGL inhibitors

US11608347B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Ann Catherine Petersen · Basel, CH
• Joerg Benz · Rheinfelden (Baden), DE
• Uwe Grether · Weil am Rhein, DE
• Benoit Hornsperger · Altkirch, FR
• Buelent Kocer · Basel, CH
• Bernd Kuhn · Sursee, CH
• Hans Richter · Weil am Rhein, DE
• Satoshi TSUCHIYA · Shizuoka, JP
• Yangcheng Qiu · Hubei, CN
• Rui Chen · Fremont, US

Key dates

• Filing date: Jul 7, 2020
• Grant date: Mar 21, 2023
• Expiry date: Mar 19, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides new heterocyclic compounds having the general formula (Ie) wherein R1, R1a and R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.