Patent · US Active

8-aminoisoquinoline compounds and uses thereof

US11612606B2 · kind B2 · utility

0Cited by

5References

29Claims

0Family size

Assignee

Genentech, Inc. · US

Inventors

Jun Liang · Los Altos Hills, US
Rohan Mendonca · South San Francisco, US
Michael Siu · Burlingame, US
John Tellis · San Mateo, US
Weiru Wang · Lafayette, US
BinQing Wei · Belmont, US
Bryan Chan · South San Francisco, US
Edna F. Choo · San Francisco, US
Joy Drobnick · South San Francisco, US
Lewis Gazzard · Belmont, US
Timothy Heffron · Burlingame, US

Key dates

Filing date	Oct 3, 2019
Grant date	Mar 28, 2023
Priority date	—
Expiry date	Oct 14, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D519/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

3-Carbonylamino-8-aminoisoquinoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the 3-carbonylamino-8-aminoisoquinoline compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.