Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors
US11613542B2 · kind B2 · utility
0Cited by
9References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 15, 2018 |
| Grant date | Mar 28, 2023 |
| Priority date | — |
| Expiry date | Aug 15, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to sulfonylureas and sulfonylthioureas comprising a 5-membered nitrogen-containing heteroaryl ring attached to the sulfonyl group, wherein the heteroaryl ring is substituted with a nitrogen-containing group R1′ wherein R1 contains from 1 to 7 atoms other than hydrogen or halogen. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.