Compositions and methods for reducing serum triglycerides

US11633471B2 · kind B2 · utility

Assignees

• UNM RAINFOREST INNOVATIONS · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Bryce Chackerian · Albuquerque, US
• Alan T. Remaley · Bethesda, US
• Marcelo Amar · Gaithersburg, US
• Alexandra Fowler · Albuquerque, US

Key dates

• Filing date: Mar 6, 2019
• Grant date: Apr 25, 2023
• Expiry date: May 6, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2795/18133
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An immunogen generally includes a virus-like particle and an antigen linked to the virus-like particle. The antigen includes an antigenic portion of a polypeptide, wherein the polypeptide inhibits lipoprotein lipase (LPL) activity by binding to LPL. In some embodiments, the polypeptide is at least a portion of angiopoietin-like 3 (ANGPTL3). In other embodiments, the polypeptide is at least a portion of angiopoietin-like 4 (ANGPTL4). In other embodiments, the polypeptide at least a portion of angiopoietin-like 8 (ANGPTL8). In some embodiments, the virus-like particle is a Qbeta immunogenic carrier. In some of these embodiments, the antigen is linked to the virus-like particle through a Gly-Gly-Gly-Cys linker at the C-terminal of the antigen.