Processes for the preparation of sugammadex

US11634511B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Jamie M. McCabe Dunn · Cranford, US
• Nadine Kuhl · Garwood, US
• Wenyong Chen · Princeton, US
• Yang Cao · Niskayuna, US
• Donald R. Gauthier, Jr. · Westfield, US
• Alan Hyde · Jersey City, US
• Susan L. Zultanski · Brooklyn, US

Key dates

• Filing date: Jun 3, 2019
• Grant date: Apr 25, 2023
• Expiry date: Jun 3, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08B37/0012
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides processes for the preparation of sugammadex: (I) In one aspect, there is provided a process for the preparation of sugammadex from 8-per-deoxy-8-bromo-γ-cyclodextrin and 3-mercaptopropionic acid. In another aspect, there is provided an alternative process for the preparation of sugammadex from 8-per-deoxy-8-bromo-γ-cyclodextrin and disodium 3 -mercaptopropionate. In another aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-γ-cyclod extrin, which may be used in the production of sugammadex. In one such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-y-cyclodextrin from γ-cyclodextrin and a brominating agent. In another such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-γ-cyclodextrin comprising, inter alia, reacting γ-cyclodextrin with an electrophilic brominating agent, a deoxygenating agent, and an acid in the presence of an organic solvent.