Process for the preparation of tricyclic PI3K inhibitor compounds and methods for using the same for the treatment of cancer

US11643421B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Andreas Stumpf · Leverkusen, DE
• Remy Angelaud · San Francisco, US
• Andrew McClory · South San Francisco, US
• Herbert Yajima · San Francisco, US
• Chudi Ndubaku · Oakland, US
• Alan G. Olivero · South San Francisco, US

Key dates

• Filing date: Dec 8, 2020
• Grant date: May 9, 2023
• Expiry date: Jun 1, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides for methods for preparing tricyclic PI3K inhibitor compounds in high yield and purity in aqueous solvent systems.