Method for determining lymphoma type and providing treatment

US11646099B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• British Columbia Cancer Agency · CA
• Mayo Foundation for Medical Education and Research · US
• Julius-Maximilians-Universitat Wurzburg · DE
• Boatd of Regents of the University of Nebraska · US
• Oslo University Hospital HF · NO
• HOSPITAL CLÍNIC DE BARCELONA · ES
• UNIVERSITAT DE BARCELONA · ES
• Institut D'Investigacions Biomédiques Pi I Sunyer (IDIBAPS) · ES
• Robert Bosch Gesellschaft feuer medizinische Forshung mbH · DE
• Oregon Health & Science University · US
• City of Hope · US
• The Cleveland Clinic Foundation · US

Inventors

• Louis M. Staudt · Silver Spring, US
• Christian Steidl · North Vancouver, CA
• Anja Mottok · Vancouver, CA
• George W. Wright · Rockville, US
• David William Scott · Vancouver, CA
• Lisa M. Rimsza · Tucson, US
• Andreas Rosenwald · Würzburg, DE
• Randy D. Gascoyne · North Vancouver, CA
• Timothy C. Greiner · Gilliatt, US
• Dennis Weisenburger · Glendora, US
• Erlend B. Smeland · Oslo, NO
• Jan Delabie · Toronto, CA
• Elias Campo Guerri · Barcelona, ES
• German Ott · Bietigheim-Bissingen, DE
• Rita M. Braziel · West Linn, US
• Elaine S. Jaffe · Great Falls, US
• Kai Fu · Omaha, US
• Wing C. Chan · Pasadena, US
• Joo-hyun SONG · Nae-myeon, KR
• James Robert Cook · Shaker Heights, US

Key dates

• Filing date: Dec 13, 2019
• Grant date: May 9, 2023
• Expiry date: Nov 23, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Computer technology
• WIPO sector: Electrical engineering

Abstract

In embodiments of the invention, the invention provides a method for distinguishing between lymphoma types based on gene expression measurements. In embodiments, the invention distinguishes between PMBCL and DLBCL based on gene expression signatures, and can further distinguish between DLBCL subtypes. In embodiments of the invention, the distinctions are used in methods of treatment.