Patent · US Active

Process for preparing beta 3 agonists and intermediates

US11649243B2 · kind B2 · utility

2Cited by

14References

9Claims

0Family size

Assignee

Merck Sharp & Dohme LLC · US

Inventors

Feng Xu · Durham, US
Zhuqing Liu · Edison, US
Richard Desmond · Metuchen, US
Jeonghan Park · Flanders, US
Alexei Kalinin · Kingston, CA
Birgit Kosjek · Westfield, US
Hallena Strotman · Somerville, US
Hongmei Li · Hackettstown, US
Johannah Moncecchi · Waltham, US

Key dates

Filing date	Aug 11, 2021
Grant date	May 16, 2023
Priority date	—
Expiry date	Aug 11, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.