Inhibitor-functionalized ultrasmall nanoparticles and methods thereof

US11660354B2 · kind B2 · utility

Assignees

• Memorial Sloan Kettering Cancer Center · US
• Cornell University · IT
• The Curators of the University of Missouri · US

Inventors

• Michelle S. Bradbury · Andover, US
• Thomas P. Quinn · Sunnyvale, US
• Barney Yoo · New York, US
• Wolfgang Weber · Cologne, DE
• Karim Touijer · New York, US
• Howard Scher · Tenafly, US
• Kai Ma · Ithaca, US
• Ulrich Wiesner · Ithaca, US

Key dates

• Filing date: Nov 29, 2017
• Grant date: May 30, 2023
• Expiry date: Dec 7, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/57434
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are novel conjugates containing an inhibitor (e.g., a PSMA inhibitor, e.g., a gastrin-releasing peptide receptor inhibitor) and metal chelator that are covalently attached to a macromolecule (e.g., a nanoparticle, a polymer, a protein). Such conjugates exhibit distinct properties over the free, unbound inhibitor/chelator construct.