Peptide hydrogels and use thereof

US11661439B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Joel P. Schneider · Frederick, US
• Scott Walsh · Tarrytown, US
• Stephen D. Miller · Marion, US
• Yuji Yamada · Shizuoka, JP
• Scott Durum · Frederick, US
• Caroline Andrews · Frederick, US
• Wenqing Li · Daguantang, CN
• Julie Hixon · Hagerstown, US
• Steven Tau · Manchester, US

Key dates

• Filing date: Dec 17, 2017
• Grant date: May 30, 2023
• Expiry date: Sep 16, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2513/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure provides novel anionic amphiphilic β-hairpin peptides that self-assemble under appropriate conditions to form a reversible gel-sol hydrogel that can be used, for example, to readily deliver protein therapeutics and cells by injection to a target location in a subject.