Patent · US Active

Three-dimensional structure-based humanization method

US11680110B2 · kind B2 · utility

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2Claims

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Assignee

Hoffmann-La Roche Inc. · US

Inventors

Johannes Auer · Schwaigen, DE
Guy Georges · Habach, DE
Stefan Klostermann · Schwanau, DE
Wolfgang Schaefer

Key dates

Filing date	Jul 27, 2018
Grant date	Jun 20, 2023
Priority date	—
Expiry date	Mar 17, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/565
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Herein is reported a method for the humanization of non-human antibodies using a structure-based scoring matrix. With the scoring matrix it is possible to determine (the requirement for and) the suitability of specific (back)mutations of amino acid residues at defined positions of a selected human germline sequence. The scoring matrix takes into account the topology, the three-dimensional structure and the interactions of the respective residue and change. Thereby the influence on antigen binding of a specific amino acid residue change can be determined.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.