Patent · US Active

Filter for mammalian cell culture perfusion and clarification with hydrophobic hollow fiber

US11680239B2 · kind B2 · utility

0Cited by

2References

40Claims

0Family size

Assignee

Repligen Corporation · US

Inventors

Michael Bransby · Altadena, US
Derek Carroll · Los Angeles, US
Philip Yuen · Bellevue, US

Key dates

Filing date	Dec 30, 2019
Grant date	Jun 20, 2023
Priority date	—
Expiry date	Sep 14, 2041

Classification

Technology area (CPC B)Performing Operations; Transporting
CPC primaryB01D2325/28
WIPO fieldChemical engineering
WIPO sectorChemistry

Abstract

This disclosure relates to the use of a hydrophobic hollow fiber filter for the filtration of cell cultures and other biological perfusions, due to its resistance to fouling, as well as the ability to filter solutions with a high solid content. A hydrophobic hollow fiber filter may be used within a filter housing in conjunction with a process vessel and a traditional separation system. When the system is used with alternating tangential flow or tangential flow filtration, the hydrophobic hollow fiber filter results in more effective filtration of the filtrate, leading to greater concentration of the retentate, even in solution containing high levels of solids.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.