Cyclic di-nucleotide compounds as sting agonists

US11685761B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Brian M. Andresen · Sharon, US
• Frank Bennett · Piscataway, US
• Wonsuk Chang · Princeton, US
• Matthew L. Childers · Medfield, US
• Jared N. Cumming · Garwood, US
• Jongwon Lim · Lexington, US
• Min Lu · San Diego, US
• Benjamin Wesley Trotter · Medfield, US
• Wen-Lian Wu · Edison, US

Key dates

• Filing date: Dec 17, 2018
• Grant date: Jun 27, 2023
• Expiry date: Aug 28, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.