Patent · US Active

Compounds and methods for DCAF-mediated protein degradation

US11691984B2 · kind B2 · utility

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1References

17Claims

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Assignee

THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

Benjamin F. Cravatt · San Diego, US
Vincent Matthew Crowley · Lawrence, US
Xiaoyu Zhang · Suzhou, CN

Key dates

Filing date	Oct 11, 2019
Grant date	Jul 4, 2023
Priority date	—
Expiry date	Oct 11, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/05
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are methods and compounds for inducing DDB1- and CUL4-associated factor 16 (DCAF16)-mediated protein degradation in mammalian cells. In some embodiments, also disclosed herein are methods of modulating the substrate selectivity of a DCAF16-CUL4-RBX1-DDB1 complex (CRL4) for modulating protein degradation.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.