Compounds, compositions and methods for synthesis

US11718638B2 · kind B2 · utility

Assignee

• WAVE LIFE SCIENCES LTD. · SG

Inventors

• David Butler · Medford, US
• Christopher P. Hencken · Boston, US
• Naoki Iwamoto · Watertown, US
• Pachamuthu Kandasamy · Cambridge, US
• Alvaro Andres Lanao · Middlebury, US
• Genliang Lu · Winchester, US
• Mamoru Shimizu · Uruma, JP
• Sethumadhavan Divakaramenon · Lexington, US
• Chandra Vargeese · Schwenksville, US
• Gopal Reddy Bommineni · Port Jefferson, US
• Subramanian Marappan · Acton, US

Key dates

• Filing date: Jun 21, 2018
• Grant date: Aug 8, 2023
• Expiry date: Jan 16, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.