Methods of preparing T cells for T cell therapy

US11723923B2 · kind B2 · utility

Assignees

• Kite Pharma, Inc. · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Arianne Perez · Santa Monica, US
• Marianna Sabatino · Los Angeles, US
• Steven A. Rosenberg · Potomac, US
• Nicholas P. Restifo · Chevy Chase Section Five, US

Key dates

• Filing date: Aug 6, 2019
• Grant date: Aug 15, 2023
• Expiry date: Sep 8, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2506/11
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are methods for delaying or inhibiting T cell maturation or differentiation in vitro for a T cell therapy, comprising contacting one or more T cells from a subject in need of a T cell therapy with an AKT inhibitor and at least one of exogenous Interleukin-7 (IL-7) and exogenous Interleukin-15 (IL-15), wherein the resulting T cells exhibit delayed maturation or differentiation. In some embodiments, the method further comprises administering the one or more T cells to a subject in need of a T cell therapy.