Polypeptide tagged nucleotides and use thereof in nucleic acid sequencing by nanopore detection

US11739378B2 · kind B2 · utility

Assignees

• Roche Sequencing Solutions, Inc. · US
• Roche Molecular Systems, Inc. · US

Inventors

• Frank Bergmann · Iffeldorf, DE
• Christoph Seidel · Weilheim, DE
• Andrew Trans · Bishop, US
• Dmitriy Gremyachinskiy · San Francisco, US
• Hannes Kuchelmeister · Munich, DE
• Lars Hillringhaus · Penzberg, DE

Key dates

• Filing date: Mar 15, 2021
• Grant date: Aug 29, 2023
• Expiry date: Jun 29, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2565/631
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure relates to compositions and methods based on polypeptide-tagged nucleotide, and the use of such polypeptide-tagged nucleotides in nanopore devices and methods.