Neutralizing antibodies to HIV-1 Env and their use

US11760790B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Paolo Lusso · Rockville, US
• Qingbo Liu · Rockville, US
• Peter Kwong · Washington, US
• John Mascola · Rockville, US
• Young Do Kwon · Bethesda, US

Key dates

• Filing date: Feb 21, 2019
• Grant date: Sep 19, 2023
• Expiry date: Jan 12, 2040

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/162
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antibodies and antigen binding fragments that specifically bind to HIV-1 Env and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.