N3-substituted iminopyrimidinones as antimalarial agents
US11766435B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Feb 13, 2017 |
| Grant date | Sep 26, 2023 |
| Priority date | — |
| Expiry date | May 24, 2039 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods of treating malaria comprising administration of an N3-substituted iminopyrimidinone of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables R1, R2, R3, R4, R5, A, B, L, m, and n are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin V activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.