Phthalazinone compound, and preparation method therefor and medical use thereof

US11767312B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Hongfu Lu · Shanghai, CN
• Weiqiang XING · Shanghai, CN
• Yongcong Lv · Shanghai, CN
• Baojian Qi · Shanghai, CN
• Jianbiao PENG · Shanghai, CN
• Haibing GUO · Shanghai, CN

Key dates

• Filing date: Apr 5, 2023
• Grant date: Sep 26, 2023
• Expiry date: Apr 5, 2043

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a phthalazinone compound, and a preparation method therefor and the medical use thereof. In particular, disclosed are a compound as represented by formula (I), and a pharmacodynamically acceptable salt, and the use of the compound as an androgen receptor (AR) for degradation.