Cereblon modulators and uses thereof

US11771689B2 · kind B2 · utility

Assignees

• Vividion Therapeutics, Inc. · US
• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• Benjamin F. Cravatt · San Diego, US
• Matthew Patricelli · San Diego, US
• Dean Stamos · Carlsbad, US
• Gabe SIMON · San Diego, US
• Benjamin HORNING · San Diego, US
• David Weinstein · Dobbs Ferry, US
• Ekaterina VINOGRADOVA · San Antonio, US

Key dates

• Filing date: Nov 17, 2020
• Grant date: Oct 3, 2023
• Expiry date: Nov 17, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D451/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compositions and methods for modulating cereblon neosubstrates. A small molecule modulator of Formula (I*), or a pharmaceutically acceptable salt or solvate thereof can be used to modulate cereblon neosubstrates.