Patent · US Active

Polymerase mutants and use with 3′-OH unblocked reversible terminators

US11773380B1 · kind B1 · utility

0Cited by

19References

22Claims

0Family size

Assignee

AGILENT TECHNOLOGIES, INC. · US

Inventors

Michelle Cayouette · San Diego, US
Jeffrey D. Fox · Philadelphia, US
Connie Hansen · San Diego, US
Holly Hogrefe · San Diego, US
Weidong Wu · Houston, US

Key dates

Filing date	Aug 24, 2022
Grant date	Oct 3, 2023
Priority date	—
Expiry date	Aug 24, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y207/07007
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Mutant polymerases are provided that have improved ability to incorporate modified nucleotides, including 3′-OH unblocked reversible terminators. The mutant polymerases may be used in a variety of applications, such as for polynucleotide sequencing, primer extension reactions, and template-independent enzymatic oligonucleotide synthesis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.