Capsid inhibitors for the prevention of HIV

US11807625B2 · kind B2 · utility

Assignee

• Gilead Sciences, Inc. · US

Inventors

• Elena Bekerman · Castro Valley, US
• Wade Blair · Poolesville, US
• Anna Chiu · Burlingame, US
• Tomas Cihlar · Burlingame, US
• Dana J. Levine · San Leandro, US
• Winston C. Tse · Redwood City, US
• Stephen R. Yant · Boulder Creek, US
• Jim X. Zheng · Foster City, US

Key dates

• Filing date: Nov 25, 2020
• Grant date: Nov 7, 2023
• Expiry date: Nov 25, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides methods of preventing HIV in a subject, comprising administering to the subject a therapeutically effective amount of a compounds of Formula (Ia) or (Ib):or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. Methods of reducing the risk of acquiring HIV (e.g., HIV-1 and/or HIV-2) are also provided.