Compositions and methods for treating bacterial infections

US11865168B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Alexander K. Shalek · Cambridge, US
• Travis Hughes · Cambridge, US
• Marc Havens Wadsworth · Cambridge, US
• Robert Seder · Chevy Chase Section Five, US
• Mario Roederer · Bethesda, US
• Joanne L. Flynn · Pittsburgh, US
• Patricia Darrah · Bethesda, US

Key dates

• Filing date: Dec 30, 2020
• Grant date: Jan 9, 2024
• Expiry date: Dec 30, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/55594
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are compositions and methods for therapeutic and/or prophylactic treatment of an intracellular bacterial infection in a subject in need thereof, comprising one or more modulating agents, wherein the one or more modulating agents increase expression of IFNγ, IL-2, TNF, and/or IL-17 in systemic and/or lung T cells. In some embodiments, the increase of expression of IFNγ, IL-2, TNF, and/or IL-17 occurs in lung T cells. The lung T cells can be lung resident T cells or systemic T cells that are recruited to the lung. In some embodiments, the T cells are CD4+ and/or CD8+ T cells. In some embodiments, the intracellular bacterial infection is a Mycobacterium tuberculosis (MTB) infection.