Modulators of Cystic Fibrosis Transmembrane Conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulators

US11866450B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Jeremy J. Clemens · San Diego, US
• Alexander Russell Abela · San Diego, US
• Corey Anderson · San Diego, US
• Brett B. Busch · San Diego, US
• Weichao George Chen · San Diego, US
• Thomas Cleveland · San Diego, US
• Timothy Richard Coon · Carlsbad, US
• Bryan A. Frieman · Village of La Jolla, US
• Senait G. Ghirmai · San Diego, US
• Peter Diederik Jan Grootenhuis · San Diego, US
• Anton V. Gulevich · San Diego, US
• Sara S. Hadida Ruah · Village of La Jolla, US
• Clara Kuang-Ju Hsia · San Diego, US
• Ping Kang · San Diego, US
• Haripada Khatuya · San Diego, US
• Jason McCartney · Encinitas, US
• Mark Miller · San Diego, US
• Prasuna Paraselli · San Diego, US
• Fabrice Pierre · Cugnaux, FR
• Sara E. Swift · San Diego, US
• Andreas P. Termin · Encinitas, US
• Johnny Uy · San Diego, US
• Carl V. Vogel · Carlsbad, US
• Jinglan Zhou · San Diego, US

Key dates

• Filing date: May 18, 2021
• Grant date: Jan 9, 2024
• Expiry date: May 18, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D515/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.