Reagents and methods for replication, transcription, and translation in semi-synthetic organisms

US11879145B2 · kind B2 · utility

Assignee

• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• Floyd E. ROMESBERG · Village of La Jolla, US
• Vivian T. DIEN · Village of La Jolla, US
• Aaron W. FELDMAN · San Diego, US
• Rebekah J. KARADEEMA · San Diego, US
• Lingjun Li · San Jose, US
• Michael P. LEDBETTER · Village of La Jolla, US
• Anne Xiaozhou ZHOU · Village of La Jolla, US

Key dates

• Filing date: Jun 12, 2020
• Grant date: Jan 23, 2024
• Expiry date: Sep 16, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y207/07006
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are compositions, methods, cells, engineered microorganisms, and kits for increasing the production of proteins or polypeptides comprising one or more unnatural amino acids. Further provided are compositions, cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism.