Nipah virus immunogens and their use

US11890339B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• TRUSTEES OF DARTMOUTH COLLEGE · US

Inventors

• Barney Graham · Rockville, US
• Rebecca Loomis · Philadelphia, US
• Guillaume Stewart-Jones · Cambridge, US
• John Mascola · Rockville, US
• Jason McLellan · Austin, US

Key dates

• Filing date: Aug 5, 2019
• Grant date: Feb 6, 2024
• Expiry date: Oct 23, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/18234
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of immunogens comprising a recombinant Nipah virus (NiV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant NiV F ectodomain trimer and one or more G ectodomains, a multimer of NiV G ectodomains, and protein nanoparticles comprising the recombinant NiV F ectodomain trimer or an NiV G ectodomain. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits NiV infection in a subject.